Discovery of Innate Immune Agonists Using Deep Learning on High- Dimensional Phenomics
Time: 3:30 pm
day: Day One
Details:
- We apply computational methods to high content imaging of PBMCs to construct highly accurate models that discriminate between many distinct innate immune signalling pathways
- These imaging models are paired with proteomics to build a deep understanding of the relationship between high level cell behaviours and molecular signalling
- This understanding is applied to high throughput screening to identify new compounds that induce inflammation with potential applications as vaccine adjuvants and immunotherapies
