Discovery of Innate Immune Agonists Using Deep Learning on High- Dimensional Phenomics

Time: 3:30 pm
day: Day One


  • We apply computational methods to high content imaging of PBMCs to construct highly accurate models that discriminate between many distinct innate immune signalling pathways
  • These imaging models are paired with proteomics to build a deep understanding of the relationship between high level cell behaviours and molecular signalling
  • This understanding is applied to high throughput screening to identify new compounds that induce inflammation with potential applications as vaccine adjuvants and immunotherapies