Igniting IFNg Responses to Overcome Resistance with a Novel Macrophage Checkpoint
Time: 2:00 pm
day: Innate Immune Checkpoints & Activation Pre-Focus Day
Details:
- CLEVER-1 is a master immunosuppressive scavenger receptor on TAMs
- Bexmarilimab, a first in class anti-CLEVER-1 mAb, is the first macrophage checkpoint
to show single agent activity in advanced solid tumors - Bexmarilimab works by igniting IFNg responses where they do not exist, paving the
road for classical checkpoint inhibitors
