Igniting IFNg Responses to Overcome Resistance with a Novel Macrophage Checkpoint

Time: 2:00 pm
day: Innate Immune Checkpoints & Activation Pre-Focus Day


  • CLEVER-1 is a master immunosuppressive scavenger receptor on TAMs
  • Bexmarilimab, a first in class anti-CLEVER-1 mAb, is the first macrophage checkpoint
    to show single agent activity in advanced solid tumors
  • Bexmarilimab works by igniting IFNg responses where they do not exist, paving the
    road for classical checkpoint inhibitors