Low pH-Induced Polarization of Human Macrophages Toward a Pro- Tumorigenic, Wound repair Phenotype is Fully Reversed by Small Molecule Inhibitors of GPR65: Implications for Cancer Immunotherapy

Time: 10:30 am
day: Innate Immune Checkpoints & Activation Pre-Focus Day


  • The extracellular microenvironment of solid tumors is typically much more acidic than surrounding tissue
  • This acidic environment has a profound effect on macrophages and other innate immune cells, leading to a pronounced polarization of these cells toward a protumorigenic or wound repair phenotype
  • Pathios proprietary small molecule GPR65 inhibitors are able to fully counteract this polarization in vitro and bring about activation of the innate immune system in viv